Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts.

doi:10.3390/cells8101300

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Article

Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts.

Cells - 22 Oct 2019

Dorris Emma R, Linehan Eimear, Trenkmann Michelle, Veale Douglas J, Fearon Ursula, Wilson Anthony G

Abstract excerpt

rs26232, located in intron one of C5orf30, is associated with the susceptibility to and severity of rheumatoid arthritis (RA). Here, we investigate the relationship between this variant and the biological activities of rheumatoid arthritis synovial fibroblasts (RASFs). RASFs were isolated from the knee joints of 33 RA patients. The rs26232 genotype was determined and cellular migration, invasion, and apoptosis...

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Identifiers

PMID: 31652652
DOI: 10.3390/cells8101300
PMCID: PMC6829881

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