C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis.

doi:10.1073/pnas.1501947112

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Article

C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Muthana Munitta, Hawtree Sarah, Wilshaw Adam, Linehan Eimear, Roberts Hannah, Khetan Sachin, Adeleke Gbadebo, Wright Fiona, Akil Mohammed, Fearon Ursula, Veale Douglas, Ciani Barbara, Wilson Anthony G

Abstract excerpt

The variant rs26232, in the first intron of the chromosome 5 open reading frame 30 (C5orf30) locus, has recently been associated with both risk of developing rheumatoid arthritis (RA) and severity of tissue damage. The biological activities of human C5orf30 are unknown, and neither the gene nor protein show significant homology to any other characterized human sequences. The C5orf30 gene is present only in...

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PMID: 26316022
DOI: 10.1073/pnas.1501947112
PMCID: PMC4577169

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