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Variants in <i>ALDH1A2</i> reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis

2021-09-13

Abstract excerpt

Over 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there are currently no licensed disease modifying treatments for this disabling condition. Common polymorphic variants in ALDH1A2 , that encodes the key enzyme in the synthesis of all-trans retinoic acid (atRA), have been associated with severe hand OA. In this study, we sought to elucidate the biological significance of this asso...

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Literature Corpus work
6662b128-04ee-57d0-94e2-b753fe2bbb73
DOI
10.1101/2021.09.10.457848
Open publication

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