POLK and KCNK17 as novel candidate genes for type 2 diabetes via stress response and ion channel regulation.

Abstract excerpt

PURPOSE: Pancreatic beta-cell dysfunction is a central pathological feature of type 2 diabetes (T2D). However the cell type-specific causal genes underlying β-cell dysfunction remain incompletely defined. METHODS: We analyzed scRNA-seq data from 17 patients with T2D and 17 healthy controls. Four machine learning models (Random Forest, XGBoost, SVM, L2 regularized logistic regression) were applied to identify key...

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