Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pulmonary-Intestinal Axis: Shared Genetic Basis and Mediating Factors Identified Through Multi-Omics Analysis.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Zhang Zhenzhu, Liu Haoyue, Su Yihang, Wang Chengwen, Wang Wei, Li Yinglin, Zhang Xiaobao, Gao Chenguang, Tian Xue, Zhao Chunqing

Abstract excerpt

Background: Chronic obstructive pulmonary disease (COPD) is a systemic condition with comorbidities beyond the lung (eg, cardiovascular and metabolic disorders), and gastrointestinal (GI) disorders are also common. The shared genetic basis of COPD-GI comorbidity and its mediating factors remain unclear. We hypothesized that COPD and GI diseases share pleiotropic genetic architecture implicating lipid-metabolic...

Topics

Join the communities discussing this publication.

Comorbidity
Gastrointestinal Diseases
Lipid Metabolism
Mendelian Randomization Analysis
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 41978582
DOI: 10.2147/COPD.S561645
PMCID: PMC13070119

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pulmonary-Intestinal Axis: Shared Genetic Basis and Mediating Factors Identified Through Multi-Omics Analysis.PMID 41978582Read ↗

Genome-wide assessment of shared genetic landscape of idiopathic pulmonary fibrosis and its comorbidities.Semantic proximity Read ↗

Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD.Semantic proximity Read ↗

A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseasesSemantic proximity Read ↗

Interplay of Chronic Obstructive Pulmonary Disease and Colorectal Cancer Development: Unravelling the Mediating Role of Fatty Acids through a Comprehensive Multi-Omics AnalysisSemantic proximity Read ↗

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary diseaseSemantic proximity Read ↗

Interplay of chronic obstructive pulmonary disease and colorectal cancer development: unravelling the mediating role of fatty acids through a comprehensive multi-omics analysisSemantic proximity Read ↗

Multi-omics integration identifies associations between large high-density lipoprotein and lung function, asthma, and COPD: evidence from genetic and population-based analyses.Semantic proximity Read ↗

Genetic and observational associations of lung function with gastrointestinal tract diseases: pleiotropic and mendelian randomization analysis.Semantic proximity Read ↗

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.Semantic proximity Read ↗

Integrative multi-omic analyses identify major axes of heterogeneity in chronic obstructive pulmonary disease and uncover their molecular contributorsSemantic proximity Read ↗

Genetic Architecture of Comorbidity Between Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: Exploring Shared Mechanisms and Potential Therapeutic Targets.Semantic proximity Read ↗

Comparative genomic analysis reveals shared and distinct mechanisms of nasal polyps and chronic rhinosinusitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.