Article
Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma.
Allergy - 1 Jan 2013
Ried J S, Baurecht H, Stückler F, Krumsiek J, Gieger C, Heinrich J, Kabesch M, Prehn C, Peters A, Rodriguez E, Schulz H, Strauch K, Suhre K, Wang-Sattler R, Wichmann H-E, Theis F J, Illig T, Adamski J, Weidinger S
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified many risk loci for asthma, but effect sizes are small, and in most cases, the biological mechanisms are unclear. Targeted metabolite quantification that provides information about a whole range of pathways of intermediary metabolism can help to identify biomarkers and investigate disease mechanisms. Combining genetic and metabolic information can...
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