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Article

Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity.

Cell genomics - 14 May 2025

Donoghue Lauren J, Benner Christian, Chang Diana, Irudayanathan Flaviyan Jerome, Pendergrass Rion K, Yaspan Brian L, Mahajan Anubha, McCarthy Mark I

Abstract excerpt

Hundreds of genetic associations for asthma have been identified, yet translating these findings into mechanistic insights remains challenging. We leveraged plasma proteomics from the UK Biobank Pharma Proteomics Project (UKB-PPP) to identify biomarkers and effectors of asthma risk or heterogeneity using genetic causal inference approaches. We identified 609 proteins associated with asthma status (269 proteins...

Read the complete abstract on PubMed

Topics

Humans
Asthma
Proteomics
Biological Specimen Banks
Biomarkers
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Female

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 40187354
DOI: 10.1016/j.xgen.2025.100840
PMCID: PMC12143328

Genes

CLEC7A
GCHFR
TDRKH
TSPAN8

Provenance

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