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Article

Comparative Biochemical Studies of Disease-Associated Human Dicer Mutations on Processing of a Pre-microRNA and snoRNA.

Biochemistry - 6 Jun 2023

Torrez Rachel M, Nagaraja Shruti, Menon Arya, Chang Louise, Ohi Melanie D, Garner Amanda L

Abstract excerpt

Dicer is an RNase III enzyme that is responsible for the maturation of small RNAs such as microRNAs. As Dicer's cleavage products play key roles in promoting cellular homeostasis through the fine-tuning of gene expression, dysregulation of Dicer activity can lead to several human diseases, including cancers. Mutations in Dicer have been found to induce tumorigenesis and lead to the development of a rare...

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Identifiers

PMID: 37130292
DOI: 10.1021/acs.biochem.2c00687
PMCID: PMC11467860

Genes

DICER1

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