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Article

MicroRNA and Rare Human Diseases.

Genes - 25 Sept 2024

Goel Himanshu, Goel Amy

Abstract excerpt

BACKGROUND: The role of microRNAs (miRNAs) in the pathogenesis of rare genetic disorders has been gradually discovered. MiRNAs, a class of small non-coding RNAs, regulate gene expression by silencing target messenger RNAs (mRNAs). Their biogenesis involves transcription into primary miRNA (pri-miRNA), processing by the DROSHA-DGCR8 (DiGeorge syndrome critical region 8) complex, exportation to the cytoplasm, and...

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PMID: 39457367
DOI: 10.3390/genes15101243
PMCID: PMC11507005

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