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Article

Two divergent VAR2CSA lineages with distinct evolutionary signatures circulate in Plasmodium falciparum from Thailand.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2026

Chaikitgosiyakul Sethawud, Kuamsab Napaporn, Tia Taweesak, Putaporntip Chaturong, Jongwutiwes Somchai

Abstract excerpt

VAR2CSA is the primary target for vaccines against placental malaria; however, its extensive polymorphism hinders vaccine development. While most studies focus on partial fragments, full-length sequence data from clinical isolates remain scarce. We determined the complete var2csa coding sequences (9.1-9.9 kb) of 31 symptomatic Plasmodium falciparum isolates from five endemic provinces in Thailand using long-range...

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PMID: 41791500
DOI: 10.1016/j.meegid.2026.105916

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