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Article

Gene-environment interactions: lifetime cognitive activity, APOE genotype, and β-amyloid burden.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Jun 2014

Wirth Miranka, Villeneuve Sylvia, La Joie Renaud, Marks Shawn M, Jagust William J

Abstract excerpt

Carriers of the apolipoprotein E (APOE) ε4 allele, the major genetic risk for Alzheimer's disease (AD), harbor an increased load of β-amyloid (Aβ) plaque burden that is felt to be a major instigator of AD development. Data has suggested that lifestyle factors may reduce AD risk by directly mitigating Aβ pathology, which could be particularly beneficial in APOE ε4 carriers. We therefore examined the interaction...

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Share to Apolipoprotein E4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24948815
DOI: 10.1523/JNEUROSCI.4612-13.2014
PMCID: PMC4061397

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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