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Article

How to discover novel genes that cause Parkinson's disease.

Current opinion in neurobiology - 1 Jun 2026

Farrer Matthew J

Abstract excerpt

Parkinson's disease (PD) is an age-associated movement disorder with many variable symptoms, albeit with no treatments to slow or halt clinical progression. Its etiology is multifactorial with a genetic heritability of ∼27%, and even monogenic disease in families manifests with incomplete/reduced penetrance and variable expressivity. Over the past 28 years, genetic linkage studies have identified causal mutations...

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Identifiers

PMID: 41791140
DOI: 10.1016/j.conb.2026.103179

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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