Article
Uncovering the genetic basis of Parkinson's disease globally: from discoveries to the clinic.
The Lancet. Neurology - 1 Dec 2024
Lim Shen-Yang, Tan Ai Huey, Ahmad-Annuar Azlina, Okubadejo Njideka Ulunma, Lohmann Katja, Morris Huw R, Toh Tzi Shin, Tay Yi Wen, Lange Lara M, Bandres-Ciga Sara, Mata Ignacio, Foo Jia Nee, Sammler Esther, Ooi Joshua Chin Ern, Noyce Alastair J, Bahr Natascha, Luo Wei, Ojha Rajeev, Singleton Andrew B, Blauwendraat Cornelis, Klein Christine
Abstract excerpt
Knowledge on the genetic basis of Parkinson's disease has grown tremendously since the discovery of the first monogenic form, caused by a mutation in α-synuclein, and with the subsequent identification of multiple other causative genes and associated loci. Genetic studies provide insights into the phenotypic heterogeneity and global distribution of Parkinson's disease. By shedding light on the underlying...
Topics
- Humans
- Parkinson Disease
- alpha-Synuclein
- Genetic Predisposition to Disease