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Article

Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits.

Medicine - 5 Dec 2025

Zeng Bin, Xu Shuling, Zhou Dongqi, Chen Rumeng, Ding Yining, Wu Zhu, Zheng Zhiwei, Liu Menghua, He Binsheng, Li Sen, Bao Meihua

Abstract excerpt

Intervertebral disc degeneration (IVDD) is a main contributor to low back pain, often considered a chronic condition. This highlights the importance of early identification of potential risk factors and implementation of preventive measures. Therefore, comprehending the causal factors underlying IVDD is crucial. We employed independent genetic variants from 108 traits as instrumental variables to analyze the...

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Body Mass Index
Genetic Predisposition to Disease
Intervertebral Disc Degeneration
Low Back Pain
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41366924
DOI: 10.1097/MD.0000000000045603
PMCID: PMC12688724

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