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Article

Telomere length is causally connected to brain MRI image derived phenotypes: A mendelian randomization study.

PloS one - 1 Jan 2022

Salih Ahmed, Galazzo Ilaria Boscolo, Petersen Steffen E, Lekadir Karim, Radeva Petia, Menegaz Gloria, Altmann André

Abstract excerpt

Recent evidence suggests that shorter telomere length (TL) is associated with neuro degenerative diseases and aging related outcomes. The causal association between TL and brain characteristics represented by image derived phenotypes (IDPs) from different magnetic resonance imaging (MRI) modalities remains unclear. Here, we use two-sample Mendelian randomization (MR) to systematically assess the causal...

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Identifiers

PMID: 36399449
DOI: 10.1371/journal.pone.0277344
PMCID: PMC9674175

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