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Article

Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study.

Journal of translational medicine - 31 May 2023

Gu Yifei, Jin Qianmei, Hu Jinquan, Wang Xinwei, Yu Wenchao, Wang Zhanchao, Wang Chen, Liu Yang, Chen Yu, Yuan Wen

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully understood. This study aims to reveal the causal effect of circulation metabolites on OA susceptibility. METHODS: A two-sample Mendelian Randomization (MR) analysis was performed to estimate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Rheumatoid Arthritis Research and Therapies

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Identifiers

PMID: 37259122
DOI: 10.1186/s12967-023-04165-9
PMCID: PMC10230782

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