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Article

Lipids and Lipid-Lowering Drugs With Risk of Intervertebral Disc Degeneration: A Mendelian Randomization Study.

Genetics research - 1 Jan 2026

Xu Aochen, Yuan Jiabin

Abstract excerpt

This study examined whether circulating lipid traits and lipid-lowering drug targets are causally associated with intervertebral disc degeneration (IVDD) using a Mendelian randomization (MR) framework. We analyzed summary-level data from genome-wide association studies (GWASs) covering apolipoproteins, lipid parameters, and IVDD. Univariable analysis revealed that inherently elevated high-density lipoprotein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42528182
DOI: 10.1155/genr/5378960
PMCID: PMC13420274

Genes

NPC1L1
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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