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Article

Neutral Theory and Rapidly Evolving Viral Pathogens.

Molecular biology and evolution - 1 Jun 2018

Frost Simon D W, Magalis Brittany Rife, Kosakovsky Pond Sergei L

Abstract excerpt

The evolution of viral pathogens is shaped by strong selective forces that are exerted during jumps to new hosts, confrontations with host immune responses and antiviral drugs, and numerous other processes. However, while undeniably strong and frequent, adaptive evolution is largely confined to small parts of information-packed viral genomes, and the majority of observed variation is effectively neutral. The...

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Identifiers

PMID: 29688481
DOI: 10.1093/molbev/msy088
PMCID: PMC6279309

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