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Host Aging Induces a Senescent-Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae.

Aging cell - 1 Mar 2026

Battaglia Michael C, Bhalla Manmeet, Marzullo Brandon, Betadpur Anagha, Lenhard Alexsandra P, Mohamed Rania Hassan, Kalem Murat C, Heinzinger Lauren R, Leus Pathricia A, Labarron Samuel, Garrett-Sinha Lee Ann, Mecsas Joan, Blumental-Perry Anna, Bou Ghanem Elsa N

Abstract excerpt

Aging drives increased susceptibility to respiratory infections by Streptococcus pneumoniae (pneumococci). Polymorphonuclear leukocytes (PMNs) are among the first responders in the lung following pneumococcal infection and are required for bacterial clearance. However, PMN antimicrobial function declines with age. To identify mechanisms underlying this decline, we performed RNA sequencing on PMNs in the lungs of...

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PMID: 41771759
DOI: 10.1111/acel.70435
PMCID: PMC12953003

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