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Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging

21 Dec 2020

Abstract excerpt

Significance The elderly exhibit susceptibility to many infectious agents, including S. pneumoniae . A robust acute inflammatory response to S. pneumoniae is associated with severe disease. S. pneumoniae triggers canonical autophagy in nonprofessional phagocytes, but its role in macrophages is largely unexplored. We found that BMDMs utilize LAP, rather than canonical autophagy, to both eliminate S. pneumoniae and...

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PMID: 33376222
DOI: 10.1073/pnas.2015368117

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