Article
The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections.
International journal of molecular sciences - 25 Feb 2017
Yanagi Shigehisa, Tsubouchi Hironobu, Miura Ayako, Matsuo Ayako, Matsumoto Nobuhiro, Nakazato Masamitsu
Abstract excerpt
Pneumonia generates considerable negative impacts on the elderly. Despite the widespread uses of vaccines and appropriate antibiotics, the morbidity and mortality of elderly pneumonia are significantly higher compared to the counterparts of young populations. The definitive mechanisms of high vulnerability in the elderly against pathogen threats are unclear. Age-associated, chronic low-grade inflammation augments...
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