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Article

Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance.

The Journal of clinical investigation - 2 Mar 2026

Zhu Xiu-Zhi, Zhou Yi-Fan, Ying Xiao-Han, Wang Yun-Yi, Ding Xiao-Hong, Zhang Kun-Yu, Shao Zhi-Ming, Jin Xi, Jiang Yi-Zhou, Wang Zhong-Hua

Abstract excerpt

The multi-omics data represented by genomic data from patients with metastatic triple-negative breast cancer (TNBC) is crucial for precision treatment, yet data on genomic alterations in metastatic cohorts and Chinese populations remains limited. We performed targeted sequencing of 296 metastatic TNBC samples from 296 patients treated at Fudan University Shanghai Cancer Center (October 2018 to November 2020)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41766665
DOI: 10.1172/JCI188989
PMCID: PMC12948418

Genes

PKD1
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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