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Single‐cell transcriptome sequencing reveals SPP1 ‐ CD44 ‐mediated macrophage–tumor cell interactions drive chemoresistance in TNBC

1 Jul 2024

Abstract excerpt

Abstract Triple‐negative breast cancer (TNBC) is often considered one of the most aggressive subtypes of breast cancer, characterized by a high recurrence rate and low overall survival (OS). It is notorious for posing challenges related to drug resistance. While there has been progress in TNBC research, the mechanisms underlying chemotherapy resistance in TNBC remain largely elusive. We collect single‐cell RNA...

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PMID: 38982317
DOI: 10.1111/jcmm.18525

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