Article
FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure.
Scientific reports - 20 Jul 2020
E Silva Ana Pinto, Miranda Isabel Marcos, Branco Joana, Oliveira Patricia, Faria-Ramos Isabel, Silva Raquel M, Rodrigues Acácio Gonçalves, Costa-de-Oliveira Sofia
Abstract excerpt
Invasive aspergillosis (IA) is a potentially lethal infection that affects mostly immunocompromised patients caused by Aspergillus fumigatus. Echinocandins are a second-line therapy against IA, used as a salvage therapy as well as for empirical or prophylactic therapy. Although they cause lysis of growing hyphal tips, they are considered fungistatic against molds. In vivo echinocandins resistance is uncommon;...
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