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Article

Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point-Mutation-Mediated Resistance.

Angewandte Chemie (International ed. in English) - 26 Feb 2024

Jospe-Kaufman Moriah, Ben-Zeev Efrat, Mottola Austin, Dukhovny Anna, Berman Judith, Carmeli Shmuel, Fridman Micha

Abstract excerpt

Echinocandins are a class of antifungal drugs that inhibit the activity of the β-(1,3)-glucan synthase complex, which synthesizes fungal cell wall β-(1,3)-glucan. Echinocandin resistance is linked to mutations in the FKS gene, which encodes the catalytic subunit of the glucan synthase complex. We present a molecular-docking-based model that provides insight into how echinocandins interact with the target Fks...

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Identifiers

PMID: 38161189
DOI: 10.1002/anie.202314728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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