Article
Network modeling of sporadic colorectal cancer reveals the importance of off-target effects of Cyclooxygenase inhibitors.
NPJ systems biology and applications - 27 Feb 2026
Gebhart Anthony R, Berns Manon M M, Snoeys Jan, Elassaiss-Schaap Jeroen, de Lange Elizabeth C M
Abstract excerpt
Cyclooxygenase (COX) inhibitors (COXIBs) have shown preventive and therapeutic potential for colorectal cancer (CRC). In addition to inhibiting COX, approved COXIBs also target COX-independent pathways, including NF-κB and AKT. We evaluated how inhibition of various COXIB targets affects cell proliferation and apoptosis using a Boolean model incorporating the effect of several genetic mutations linked to CRC. The...
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