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Article

Palmitic acid-evoked PKR/JNK activation and SIRT1 decline: Association with myocardial ageing phenotype changes and partial reversal by inhibitors.

Tissue & cell - 1 Aug 2026

Li Wenxi, Liu Guoshun, Huang Shuijin, Lin Tianhai, Peng Cheng, Liu Feng

Abstract excerpt

OBJECTIVE: This preliminary study examines possible associations between palmitic acid (PA) exposure and ageing-associated features in cardiomyocytes. METHODS: Cells were treated with PA at0.08-0.8 mmol/L concentrations or for different duration (12-72 h). Cell viability was assessed by using the MTT assay, Cell cycle was analyzed by flow cytometry, and ROS levels were measured by using a ROS kit. We performed...

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Identifiers

PMID: 41759332
DOI: 10.1016/j.tice.2026.103399

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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