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Article

Molecular mechanism by which palmitate inhibits PKR autophosphorylation.

Biochemistry - 15 Feb 2011

Cho Hyunju, Mukherjee Shayantani, Palasuberniam Pratheeba, Pillow Lisa, Bilgin Betul, Nezich Catherine, Walton S Patrick, Feig Michael, Chan Christina

Abstract excerpt

PKR (double-stranded RNA-activated protein kinase) is an important component of the innate immunity, antiviral, and apoptotic pathways. Recently, our group found that palmitate, a saturated fatty acid, is involved in apoptosis by reducing the autophosphorylation of PKR at the Thr451 residue; however, the molecular mechanism by which palmitate reduces PKR autophosphorylation is not known. Thus, we investigated how...

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Identifiers

PMID: 21192654
DOI: 10.1021/bi101923r
PMCID: PMC3035770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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