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Article

Downregulation of Sirt6 by CD38 promotes cell senescence and aging

6 Dec 2022

Abstract excerpt

Decreased nicotinamide adenine dinucleotide (NAD+) levels accompany aging. CD38 is the main cellular NADase. Cyanidin-3-O-glucoside (C3G), a natural inhibitor of CD38, is a well-known drug that extends the human lifespan. We investigated mechanisms of CD38 in cell senescence and C3G in antiaging. Myocardial H9c2 cells were induced to senescence with D-gal. CD38 siRNA, C3G and UBCS039 (a chemical activator of...

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PMID: 36490326
DOI: 10.18632/aging.204425

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