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Article

Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants.

Nature medicine - 1 Jun 2024

Rahman Md Shafiqur, Harrison Emma, Biggs Heather, Seikus Chloe, Elliott Paul, Breen Gerome, Kingston Nathalie, Bradley John R, Hill Steven M, Tom Brian D M, Chinnery Patrick F

Abstract excerpt

A leading explanation for translational failure in neurodegenerative disease is that new drugs are evaluated late in the disease course when clinical features have become irreversible. Here, to address this gap, we cognitively profiled 21,051 people aged 17-85 years as part of the Genes and Cognition cohort within the National Institute for Health and Care Research BioResource across England. We describe the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38745010
DOI: 10.1038/s41591-024-02960-5
PMCID: PMC11186791

Genes

APOE

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