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Sex and APOE genotype differences related to statin use in the aging population

1 Jan 2021

Abstract excerpt

Abstract Background Significant evidence suggests that the cholesterol‐lowering statins can affect cognitive function and reduce the risk for Alzheimer's disease (AD) and dementia. These potential effects may be constrained by specific combinations of an individual's sex and apolipoprotein E ( APOE ) genotype. Methods Here we examine data from 252,327 UK Biobank participants, aged 55 or over, and compare the...

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PMID: 33969178
DOI: 10.1002/trc2.12156

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