Back to search

Article

Glucagon-like peptide-1 receptor agonist initiation and risk of clinically recorded Alzheimer's disease-type dementia in older adults with type 2 diabetes: a target trial emulation using causal machine learning

2026-08-24

Abstract excerpt

<h4>Background: </h4> Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors are increasingly used for type 2 diabetes. Despite established metabolic, cardiovascular, and renal benefits, it remains uncertain whether GLP-1 receptor agonists are associated with longer clinically recorded Alzheimer's disease (AD)-type dementia-free survival than sulfonylureas (SU) or S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
df4bf9c5-8f21-5b49-901e-b307b869e446
DOI
10.64898/2026.08.21.26361012
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Glucagon-like peptide-1 receptor agonist initiation and risk of clinically recorded Alzheimer's disease-type dementia in older adults with type 2 diabetes: a target trial emulation using causal machine learningDOI 10.64898/2026.08.21.26361012
Drug repurposing of metformin for Alzheimer’s disease: Combining causal inference in medical records data and systems pharmacology for biomarker identificationSemantic proximity
Phenotype-based targeted treatment of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes.Semantic proximity
Effect of initiating an ARB- versus ACEI-based regimen on dementia risk, a target trial emulation of 2.5 million US VeteransSemantic proximity
CauReL: Dynamic Counterfactual Learning for Precision Drug Repurposing in Alzheimer's DiseaseSemantic proximity
Identifying incident dementia by applying machine learning to a very large administrative claims datasetSemantic proximity
Comparative Mortality Risk of Aripiprazole, Olanzapine, Quetiapine and Risperidone in Alzheimer’s Disease: A Real□World Cohort Study with Treatment Effect Heterogeneity AnalysisSemantic proximity
The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data.Semantic proximity
The association between type 2 diabetes disease trajectories and dementia incidenceSemantic proximity
Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomization studySemantic proximity
Medication-Wide Association Study of Alzheimer’s Disease and Related Dementias: Identifying Drug Candidates from Electronic Health Records through Explainable AISemantic proximity
Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomisation studySemantic proximity
Randomized metformin and cognitive outcomes in the Diabetes Prevention Program Outcomes StudySemantic proximity
Select a neighboring publication to make it the new centre.