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Article

Impact of NQO1, GSTM1 and GSTT1 genetic variants on susceptibility and relapse in childhood acute lymphoblastic leukemia.

Human immunology - 1 Apr 2026

Pereira Nathália de Sousa, Fujita Thiago Cezar, Coral de Oliveira Carlos Eduardo, Trigo Fausto Celso, Panis Carolina, Amarante Marla Karine

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is a multifactorial malignancy influenced by genetic and environmental factors. Polymorphisms in detoxification enzymes such as NQO1, GSTM1, and GSTT1 may modulate susceptibility and treatment response. This case-control study evaluated 74 children with ALL and 115 cancer-free controls from southern Brazil. Genomic DNA was analyzed for NQO1 rs1800566 (C609T) by PCR-RFLP and for...

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Source

Identifiers

PMID: 41747561
DOI: 10.1016/j.humimm.2026.111685

Genes

NQO1
GSTM1
GSTT1

Variants

rs1800566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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