Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.

doi:10.1007/s11033-012-2174-y

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Article

Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.

Molecular biology reports - 1 Feb 2013

Ouerhani Slah, Cherif Nouha, Bahri Ikbel, Safra Ines, Menif Samia, Abbes Salem

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the major pediatric cancer in developed countries. The etiology of ALL remains poorly understood, with few established environmental risk factors. These risks were influenced by co-inheritance of multiple low-risk genetic polymorphisms such as variants within cytochrome P450A1 (CYP1A1), NADPH: quinone oxidoreductase (NQO1) and Thiopurine methyltransferase (TPMT) genes. In...

Topics

Adolescent
Adult
Case-Control Studies
Cytochrome P-450 CYP1A1
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Logistic Models
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyltransferases

Models, Genetic

NAD(P)H Dehydrogenase (Quinone)

Polymorphism, Single Nucleotide

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Risk

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 23065291
DOI: 10.1007/s11033-012-2174-y

Genes

TPMT
NQO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23065291-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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