Mutant Kras Dosage and Chromothripsis: The Right Ingredients for a Pancreatic Cancer Catastrophe.

Abstract excerpt

Pancreatic ductal adenocarcinoma is a deadly disease requiring early identification but this is a challenging task in humans. Therefore, disease modeling in mice could provide important insights into early genetic events. In an article in Nature, Mueller et al. show that changes in mutant Kras allele dosage and chromothripsis are important events, both for tumor progression and to establish genetic contingencies...

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