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Article

Hypothalamic-pituitary deficiency after radiation in childhood cancer survivors is associated with rare variants in TNS2.

The Journal of clinical endocrinology and metabolism - 15 Jul 2026

Yoshida Tomoko, Wang Fan, Moon Wonjong, Mostoufi-Moab Sogol, Wang Huiqi, Neupane Achal, Wang Jian, Sapkota Yadav, Wilson Carmen L, Mirzaei Sedigheh, Wang Zhaoming, Zhang Jinghui, Merchant Thomas E, Armstrong Gregory T, Ness Kirsten K, Hudson Melissa M, Yasui Yutaka, Delaney Angela

Abstract excerpt

CONTEXT: Radiation to the hypothalamic-pituitary (HP) region (HP-RT) is a strong risk factor for HP deficiency among childhood cancer survivors (survivors). However, there is inter-individual variability in developing HP deficiency after similar HP-RT dose exposures. OBJECTIVES: To assess the genetic contribution to developing deficiencies of GH (GHD), LH/FSH (LH/FSHD), thyroid-stimulating hormone deficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41739851
DOI: 10.1210/clinem/dgag080
PMCID: PMC13178003

Genes

HP
TNS2
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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