A High-risk Haplotype for Premature Menopause in Childhood Cancer Survivors Exposed to Gonadotoxic Therapy.

doi:10.1093/jnci/djx281

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A High-risk Haplotype for Premature Menopause in Childhood Cancer Survivors Exposed to Gonadotoxic Therapy.

Journal of the National Cancer Institute - 1 Aug 2018

Brooke Russell J, Im Cindy, Wilson Carmen L, Krasin Matthew J, Liu Qi, Li Zhenghong, Sapkota Yadav, Moon WonJong, Morton Lindsay M, Wu Gang, Wang Zhaoming, Chen Wenan, Howell Rebecca M, Armstrong Gregory T, Bhatia Smita, Mostoufi-Moab Sogol, Seidel Kristy, Chanock Stephen J, Zhang Jinghui, Green Daniel M, Sklar Charles A, Hudson Melissa M, Robison Leslie L, Chemaitilly Wassim, Yasui Yutaka

Abstract excerpt

Background: Childhood cancer survivors are at increased risk of therapy-related premature menopause (PM), with a cumulative incidence of 8.0%, but the contribution of genetic factors is unknown. Methods: Genome-wide association analyses were conducted to identify single nucleotide polymorphisms (SNPs) associated with clinically diagnosed PM (menopause < 40 years) among 799 female survivors of childhood cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Alkylating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cancer Survivors

Share to Menopause, Premature

Share to Neoplasms

Share to Ovary

Share to Primary Ovarian Insufficiency

Share to Radiation Injuries

Share to Radiotherapy

Source

Open in PubMed Open full text

Identifiers

PMID: 29432556
DOI: 10.1093/jnci/djx281
PMCID: PMC6093389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A High-risk Haplotype for Premature Menopause in Childhood Cancer Survivors Exposed to Gonadotoxic Therapy.PMID 29432556Read ↗

Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE.Semantic proximity Read ↗

Rare coding variants in DNA damage repair genes associated with timing of natural menopauseSemantic proximity Read ↗

Hypothalamic-pituitary deficiency after radiation in childhood cancer survivors is associated with rare variants in TNS2.Semantic proximity Read ↗

Rare coding variants in five DNA damage repair genes associate with timing of natural menopauseSemantic proximity Read ↗

Genetic variation may modify ovarian reserve in female childhood cancer survivors.Semantic proximity Read ↗

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.Semantic proximity Read ↗

Pathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Treatment Exposures and Risk of Subsequent Neoplasms Among Long-Term Survivors of Childhood CancerSemantic proximity Read ↗

Contributions of cancer treatment and genetic predisposition to risk of subsequent neoplasms in long-term survivors of childhood cancer: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study.Semantic proximity Read ↗

Genome-wide association studies reveal novel locus with sex-/therapy-specific fracture risk effects in childhood cancer survivorsSemantic proximity Read ↗

Current and coming challenges in the management of the survivorship population.Semantic proximity Read ↗

Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry.Semantic proximity Read ↗

Ovarian Tissue Cryopreservation in Young Females Through the Oncofertility Consortium’S National Physicians CooperativeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.