Article
Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE.
Fertility and sterility - 1 Sept 2024
van der Perk M E Madeleine, Broer Linda, Yasui Yutaka, Laven Joop S E, Robison Leslie L, Tissing Wim J E, Versluys Birgitta, Bresters Dorine, Kaspers Gertjan J L, Lambalk Cornelis B, Overbeek Annelies, Loonen Jacqueline J, Beerendonk Catharina C M, Byrne Julianne, Berger Claire, Clemens Eva, van Dulmen-den Broeder Eline, Dirksen Uta, van der Pal Helena J, de Vries Andrica C H, Winther Jeanette Falck, Ranft Andreas, Fosså Sophie D, Grabow Desiree, Muraca Monica, Kaiser Melanie, Kepák Tomáš, Kruseova Jarmila, Modan-Moses Dalit, Spix Claudia, Zolk Oliver, Kaatsch Peter, Kremer Leontien C M, Brooke Russell J, Wang Fan, Baedke Jessica L, Uitterlinden André G, Bos Annelies M E, van Leeuwen Flora E, Ness Kirsten K, Hudson Melissa M, van der Kooi Anne-Lotte L F, van den Heuvel-Eibrink Marry M
Abstract excerpt
OBJECTIVE: To discover new variants associated with low ovarian reserve after gonadotoxic treatment among adult female childhood cancer survivors using a genome-wide association study approach. DESIGN: Genome-wide association study. SETTING: Not applicable. PATIENTS: A discovery cohort of adult female childhood cancer survivors from the pan-European PanCareLIFE cohort (n = 743; median age: 25.8 years), excluding...
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