Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors.

Neuro-oncology - 5 Sept 2023

Brown Austin L, Sok Pagna, Raghubar Kimberly P, Lupo Philip J, Richard Melissa A, Morrison Alanna C, Yang Jun J, Stewart Clinton F, Okcu Mehmet Fatih, Chintagumpala Murali M, Gajjar Amar, Kahalley Lisa S, Conklin Heather, Scheurer Michael E

Abstract excerpt

BACKGROUND: Survivors of pediatric central nervous system (CNS) tumors treated with craniospinal irradiation (CSI) exhibit long-term cognitive difficulties. Goals of this study were to evaluate longitudinal effects of candidate and novel genetic variants on cognitive decline following CSI. METHODS: Intelligence quotient (IQ), working memory (WM), and processing speed (PS) were longitudinally collected from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Central Nervous System Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognitive Dysfunction

Share to PPARA gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Intelligence

Source

Open in PubMed Open full text

Identifiers

PMID: 37038335
DOI: 10.1093/neuonc/noad072
PMCID: PMC10479777

Genes

PPARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors.PMID 37038335Read ↗

Genetic Predictors of Neurocognitive Outcomes in Survivors of Pediatric Brain TumorsSemantic proximity Read ↗

Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.Semantic proximity Read ↗

Using neurocognitive phenotypes to inform interventions for adult survivors of childhood cancer.Semantic proximity Read ↗

Prevalence of cancer-related cognitive impairment in pediatric patients and survivors of non-CNS cancers: A systematic review and meta-analysisSemantic proximity Read ↗

Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.Semantic proximity Read ↗

GSTP1 polymorphisms sex-specific association with verbal intelligence in survivors of pediatric medulloblastoma tumors.Semantic proximity Read ↗

Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.Semantic proximity Read ↗

Effect of cancer therapy on neural stem cellsSemantic proximity Read ↗

MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.Semantic proximity Read ↗

Assessing neuropsychological phenotypes of pediatric brain tumor survivors.Semantic proximity Read ↗

Contributions of cancer treatment and genetic predisposition to risk of subsequent neoplasms in long-term survivors of childhood cancer: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study.Semantic proximity Read ↗

Ancestral Genetic Homogeneity in Preclinical Models May Shape Outcome Differences in Pediatric Brain Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.