Article
SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin.
International journal of biological sciences - 1 Jan 2026
Wang Xiaohui, Lv Xiaowei, Jiang Honglv, Zhu Wenyun, Cao Lindong, Zhou Liang, Lin Fang, Deng Rong, Hu Li-Fang, Ma Jingjing, Li Jia-Bin, Xu Guoqiang
Abstract excerpt
Ubiquitin-fold modifier 1 (UFM1) covalently modifies protein substrates (UFMylation) and alters their biological functions. Genetic screening disclosed that enzymes in the UFMylation system play critical roles in regulating autophagy. However, it is still elusive which protein is UFMylated and how this modification modulates autophagy. Here, our quantitative proteomics and biochemical experiments identify...
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