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Article

Human Molecular Genetic and Functional Studies Identify <i>TRIM63</i> , Encoding Muscle RING Finger Protein 1, as a Novel Gene for Human Hypertrophic Cardiomyopathy

20 Jul 2012

Abstract excerpt

RATIONALE: A delicate balance between protein synthesis and degradation maintains cardiac size and function. TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle protein homeostasis by tagging the sarcomere proteins with ubiquitin for subsequent degradation by the ubiquitin-proteasome system (UPS). OBJECTIVE: To determine the pathogenic role of TRIM63 in human hypertrophic cardiomyopathy (HCM). METHODS...

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PMID: 22821932
DOI: 10.1161/circresaha.112.270207

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Human Molecular Genetic and Functional Studies Identify <i>TRIM63</i> , Encoding Muscle RING Finger Protein 1, as a Novel Gene for Human Hypertrophic CardiomyopathyPMID 22821932Read ↗

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