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Article

Shared Genetic Basis and Causality Between Epilepsy and Psychiatric Disorders: Evidence From a Comprehensive Genetic Analysis.

Brain and behavior - 1 Feb 2026

Feng Xia, Yao Huan, Xiao Gui

Abstract excerpt

BACKGROUND: Growing evidence suggests that epilepsy and psychiatric disorders may share common genetic underpinnings, yet the precise etiological relationship remains unclear. Psychiatric comorbidities affect approximately 30% of individuals with epilepsy, a rate markedly higher than in the general population, with depression (∼23%) and anxiety (∼20%) being the most prevalent. This high comorbidity burden not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Linkage Disequilibrium

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Source

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Identifiers

PMID: 41733899
DOI: 10.1002/brb3.71267
PMCID: PMC12931490

Genes

SCN1A
VRK2
ZKSCAN3
ZKSCAN4
ZSCAN23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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