Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2025

Song Qifeng, Zhang Cheng, Wang Wei, Wang Cihan, Yi Chenlong

Abstract excerpt

BACKGROUND: The genetic links between heart disease and psychiatric disorders are complex and not well understood. This study uses genome-wide association studies (GWAS) and advanced multilevel analyses to explore these connections. METHODS: We analyzed GWAS data from seven psychiatric disorders and five types of heart disease. Genetic correlations and overlaps were examined using linkage disequilibrium score...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Heart Diseases

Share to Mendelian Randomization Analysis

Share to Mental Disorders

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 39423935
DOI: 10.1016/j.pnpbp.2024.111172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders.PMID 39423935Read ↗

Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and SchizophreniaSemantic proximity Read ↗

The brain-heart axis: Integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease.Semantic proximity Read ↗

A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics.Semantic proximity Read ↗

Phenome-wide search for pleiotropic loci highlights key genes and molecular pathways for human complex traitsSemantic proximity Read ↗

Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders.Semantic proximity Read ↗

Heart-lung connections: Phenotypic and genetic insights from a large-scale genome-wide cross-trait analysisSemantic proximity Read ↗

Genetic effects and causal association analyses of 14 common conditions/diseases in multimorbidity patterns.Semantic proximity Read ↗

A global overview of pleiotropy and genetic architecture in complex traitsSemantic proximity Read ↗

Shared Genetic Basis and Causality Between Epilepsy and Psychiatric Disorders: Evidence From a Comprehensive Genetic Analysis.Semantic proximity Read ↗

Genetic pleiotropy in complex traits and diseases: implications for genomic medicine.Semantic proximity Read ↗

Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global BiobanksSemantic proximity Read ↗

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease MechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.