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Article

Characterizing the polygenic overlaps of bipolar disorder subtypes with schizophrenia and major depressive disorder.

Journal of affective disorders - 15 Jul 2022

Li Zongchang, Li David, Chen Xiaogang

Abstract excerpt

BACKGROUND: Large-scale studies have shown that bipolar I disorder (BD-I) and bipolar II disorder (BD-II) have differences in genetic association with schizophrenia (SCZ) and major depressive disorder (MDD). However, the underlying shared genetic architectures between BD subtypes and both SCZ and MDD remain largely unknown. METHODS: We applied univariate and bivariate causal mixture models (MiXeR) to estimate the...

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Identifiers

PMID: 35487438
DOI: 10.1016/j.jad.2022.04.097

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