Article

How a pathogenic mutation impairs Hsp60 functional dynamics from monomeric to fully assembled states

2024-09-09

Abstract excerpt

Heat Shock Protein 60 kDa (Hsp60) is a mitochondrial chaperonin that cooperates with Hsp10 to drive the correct folding of client proteins. Monomers M of Hsp60 (featuring equatorial, intermediate, and apical domains) first assemble into 7-meric Single rings ( S ), then pairs of S interface equatorially to form 14-meric Double rings ( D ) that accommodate clients into their lumen. Recruitment of 7 Hsp10 molecul...

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Literature Corpus work: 58d4c8f3-2fb8-5396-8981-3d6b0c399cb6
DOI: 10.1101/2024.09.09.611948

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