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Article

Mind the gap.

Structure (London, England : 1993) - 1 Jun 2023

Larsen-Ledet Sven, Stein Amelie

Abstract excerpt

Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small α-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.

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Identifiers

PMID: 37267922
DOI: 10.1016/j.str.2023.05.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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