Article

Disease-causing mutations in the G protein β5 β-propeller disrupt its chaperonin-mediated folding trajectory

2025-05-30

Abstract excerpt

The Chaperonin Containing Tailless polypeptide 1 (CCT or TRiC) is an essential cytosolic chaperone that folds multiple protein substrates, including many with β-propeller folds. One β-propeller substrate is the G protein β 5 subunit (Gβ 5 ) of Regulator of G protein Signaling (RGS) complexes that determine the duration of G protein signals in neurons. In recent work, we used cryo-electron microscopy (cryo-EM) to...

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Literature Corpus work: dafd865c-15fc-5c19-af29-7cd58cf424a2
DOI: 10.1101/2025.05.28.656654

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