Article
Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
JAMA neurology - 1 Oct 2020
Raghavan Neha S, Dumitrescu Logan, Mormino Elizabeth, Mahoney Emily R, Lee Annie J, Gao Yizhe, Bilgel Murat, Goldstein David, Harrison Theresa, Engelman Corinne D, Saykin Andrew J, Whelan Christopher D, Liu Jimmy Z, Jagust William, Albert Marilyn, Johnson Sterling C, Yang Hyun-Sik, Johnson Keith, Aisen Paul, Resnick Susan M, Sperling Reisa, De Jager Philip L, Schneider Julie, Bennett David A, Schrag Matthew, Vardarajan Badri, Hohman Timothy J, Mayeux Richard
Abstract excerpt
Importance: Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase of the disease. Objective: To examine the underlying genetic basis for brain amyloidosis in the preclinical phase of Alzheimer disease. Design, Setting, and Participants: In the first stage of this genetic association...
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