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Article

Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study.

The international journal of neuropsychopharmacology - 20 Jan 2021

Qian Li, Fan Yajuan, Gao Fengjie, Zhao Binbin, Yan Bin, Wang Wei, Yang Jian, Ma Xiancang

Abstract excerpt

BACKGROUND: Neuroticism is a strong predictor for a variety of social and behavioral outcomes, but the etiology is still unknown. Our study aims to provide a comprehensive investigation of causal effects of serum metabolome phenotypes on risk of neuroticism using Mendelian randomization (MR) approaches. METHODS: Genetic associations with 486 metabolic traits were utilized as exposures, and data from a large...

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Genome-Wide Association Study
Mendelian Randomization Analysis
Metabolome
Neuroticism
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32808022
DOI: 10.1093/ijnp/pyaa062
PMCID: PMC7816676

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