Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and BAP1 loss.

doi:10.1126/sciadv.adv5457

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Article

Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and BAP1 loss.

Science advances - 20 Feb 2026

Camp Sabrina Y, He Meng Xiao, Cuoco Michael S, Garza Amanda E, Xirenayi Sherin, Bakouny Ziad, Saad Eddy, El Masri Jad, Pimenta Erica, Meli Kevin, Labaki Chris, Titchen Breanna M, Kang Yun Jee, Horst Jack, Trowbridge Rachel, Shannon Erin, Helvie Karla, Thorner Aaron R, Vigneau Sébastien, Mayorga Angie, Kodali Jahnavi, Lachmayr Hannah, Bemus Meredith, Chen Pengsheng, Deng Haiteng, Park Jihye, Choueiri Toni K, Bi Kevin, Van Allen Eliezer M

Abstract excerpt

Transcriptional programs in renal cell carcinoma (RCC) have been linked to tumor heterogeneity and clinical outcomes, but analogous efforts to define chromatin programs shaping disease biology have been limited. Here, we generated single-cell ATAC-seq profiles from patients with RCC and integrated them with three previously published datasets to identify chromatin programs in tumor cells. We identified an...

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PMID: 41719400
DOI: 10.1126/sciadv.adv5457
PMCID: PMC12922754

Genes

BAP1

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